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Long-term high-dose B12 can mask other deficiencies (like folate), though rare at these doses

Other antiretroviral classes, including non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs), do not directly inhibit Pol- but are still associated with mitochondrial dysfunction through alternative mechanisms (107, 108)

Instead, they are often combined with ingredients that reinforce hydration, barrier strength, and overall skin comfort

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